Assessing public sector values trough the tri-axial model: empirical evidence from Spain

Purpose – The purpose of this study is to examine values among public sector employees. Furthermore, this study will identify differences according to several demographical variables with relevant policy making implications. Design/methodology/approach – Once the literature review on public sector values and the description of the Tri-axial model is presented, analysis based on a survey of 3018 public sector will be undertaken. The sample consists of employees working in the Government of Andalusia, Spain. Findings – Results reveal the domination of pragmatic values, as well as values connected to the ethical axis. The study also shows how these values vary according to several demographic characteristics of the respondents, especially when considering their level of education and their respective tenure. Research limitations/implications – When managing employees from public organizations, emphasis should be given to the development of an organizational culture that represents a configuration of both pragmatic and ethical axes. Originality/value – This study was tested with relatively a large sample size (more than three thousand observations) thus adding significant and original value to the empirical test of the Tri-axial model. Keywords – Tri-axial Model, Public-sector Values, Culture Paper type – Research pape

Anomalies in Superfluids and a Chiral Electric Effect

We analyze the chiral transport terms in relativistic superfluid hydrodynamics. In addition to the spontaneously broken symmetry current, we consider an arbitrary number of unbroken symmetries and extend the results of arXiv:1105.3733. We suggest an interpretation of some of the new transport coefficients in terms of chiral and gravitational anomalies. In particular, we show that with unbroken gauged charges in the system, one can observe a chiral electric conductivity - a current in a perpendicular direction to the applied electric field. We present a motivated proposal for the value of the associated transport coefficient, linking it to the triangle anomaly. Along the way we present new arguments regarding the interpretation of the anomalous transport coefficients in normal fluids. We propose a natural generalization of the chiral transport terms to the case of an arbitrary number of spontaneously broken symmetry currents.Comment: 30 pages; v2: Onsager-relations argument corrected, references added; v3: fixed missing line in eq. (38

LIMITS OF THE CONSTITUTIONAL MUTATION BY MEANS OF JUDICIAL INTERPRETATION: A PROPOSAL OF CATALOGING AND DEFINITION.

No presente artigo, faz-se exposição acerca da existência ou não de limites para a tarefa de interpretar a Constituição. Ao final, partindo-se da premissa de que na democracia toda semiose é limitada, propõe-se uma catalogação e definição de limites para a mudança da Constituição pela via da interpretação, dividindo tais limites em principiológicos ou teleológicos e normativos ou semióticos.In the present article, an exposition is made about the existence or not of limits for the task of interpreting the Constitution. In the end, starting from the premise that in democracy all semiosis is limited, it is proposed a cataloging and definition of limits for the change of the Constitution through the interpretation route, dividing such limits into principles or teleological and normative or semioti

Transport in holographic superfluids

We construct a slowly varying space-time dependent holographic superfluid and compute its transport coefficients. Our solution is presented as a series expansion in inverse powers of the charge of the order parameter. We find that the shear viscosity associated with the motion of the condensate vanishes. The diffusion coefficient of the superfluid is continuous across the phase transition while its third bulk viscosity is found to diverge at the critical temperature. As was previously shown, the ratio of the shear viscosity of the normal component to the entropy density is 1/(4 pi). As a consequence of our analysis we obtain an analytic expression for the backreacted metric near the phase transition for a particular type of holographic superfluid.Comment: 45 pages + appendice

A New Digital Preoperative Planning Method for Total Hip Arthroplasties

Preoperative templating is an important part of a THA. The ability to accurately determine magnification of the hip on the radiograph and apply identical magnification to the radiograph and template will improve accuracy of preoperative templating of THA. We designed a templating method using a new way of determining the hip magnification with a linear relationship between magnification of the hip and the reference object on top of the pubis symphysis; the relationship was determined on 50 radiographs. We then compared our method with two other templating methods: an analog method assuming an average hip magnification of 15% and a digital method determining the hip magnification with a one-to-one relationship between the reference object and the hip. All methods were reproducible. Uniform undersizing occurred when templating with the digital method based on the one-to-one relationship; the analog method best predicted the implanted prosthesis size, closely followed by our new digital templating method; the new method will be particularly applicable for preoperative THA when analog methods are replaced by digital methods

Capturing the essence of folding and functions of biomolecules using Coarse-Grained Models

The distances over which biological molecules and their complexes can function range from a few nanometres, in the case of folded structures, to millimetres, for example during chromosome organization. Describing phenomena that cover such diverse length, and also time scales, requires models that capture the underlying physics for the particular length scale of interest. Theoretical ideas, in particular, concepts from polymer physics, have guided the development of coarse-grained models to study folding of DNA, RNA, and proteins. More recently, such models and their variants have been applied to the functions of biological nanomachines. Simulations using coarse-grained models are now poised to address a wide range of problems in biology.Comment: 37 pages, 8 figure

An NMR-based model to investigate the metabolic phenoreversion of COVID-19 patients throughout a longitudinal study.

After SARS-CoV-2 infection, the molecular phenoreversion of the immunological response and its associated metabolic dysregulation are required for a full recovery of the patient. This process is patient-dependent due to the manifold possibilities induced by virus severity, its phylogenic evolution and the vaccination status of the population. We have here investigated the natural history of COVID-19 disease at the molecular level, characterizing the metabolic and immunological phenoreversion over time in large cohorts of hospitalized severe patients (n = 886) and non-hospitalized recovered patients that self-reported having passed the disease (n = 513). Non-hospitalized recovered patients do not show any metabolic fingerprint associated with the disease or immune alterations. Acute patients are characterized by the metabolic and lipidomic dysregulation that accompanies the exacerbated immunological response, resulting in a slow recovery time with a maximum probability of around 62 days. As a manifestation of the heterogeneity in the metabolic phenoreversion, age and severity become factors that modulate their normalization time which, in turn, correlates with changes in the atherogenesis-associated chemokine MCP-1. Our results are consistent with a model where the slow metabolic normalization in acute patients results in enhanced atherosclerotic risk, in line with the recent observation of an elevated number of cardiovascular episodes found in post-COVID-19 cohorts

Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla

Background: Pancreatic cancer, including cancer of the ampulla of Vater and bile duct, is very aggressive and has a poor five year survival rate; improved methods of patient stratification are required. Methods: We assessed the expression of calpain-1, calpain-2 and calpastatin in two patient cohorts using immunohistochemistry on tissue microarrays. The first cohort was composed of 68 pancreatic adenocarcinomas and the second cohort was composed of 120 cancers of the bile duct and ampulla. Results: In bile duct and ampullary carcinomas an association was observed between cytoplasmic calpastatin expression and patient age (P = 0.036), and between nuclear calpastatin expression and increased tumour stage (P = 0.026) and the presence of vascular invasion (P = 0.043). In pancreatic cancer, high calpain-2 expression was significantly associated with improved overall survival (P = 0.036), which remained significant in multivariate Cox-regression analysis (hazard ratio = 0.342; 95% confidence interva l = 0.157-0.741; P = 0.007). In cancers of the bile duct and ampulla, low cytoplasmic expression of calpastatin was significantly associated with poor overall survival (P = 0.012), which remained significant in multivariate Cox-regression analysis (hazard ratio = 0.595; 95% confidence interval = 0.365-0.968; P = 0.037). Conclusion: The results suggest that calpain-2 and calpastatin expression is important in pancreatic cancers, influencing disease progression. The findings of this study warrant a larger follow-up study. Keywords: Calpain, Calpastatin, Pancreas, Ampulla, Bile duct, Cance